Name: Cheesy Cajun Garlic Chicken Rotini
Prep time: 10 min
Cook time: 20 min
Total time: 30 min
Cuisine: Cajun-inspired / American Fusion
Ingredients: 2 boneless, skinless chicken breasts, cut into bite-sized chunks; 12 oz rotini pasta; 2 tbsp olive oil; 2 tbsp Cajun seasoning; 1 tsp garlic powder; ½ tsp onion powder; Salt and pepper, to taste; 4 garlic cloves, minced; 1 tbsp butter; 1 cup heavy cream; ½ cup chicken broth; 1 cup shredded mozzarella cheese; ½ cup grated Parmesan cheese; ½ cup shredded cheddar cheese; Fresh parsley, chopped (for garnish)

Jump to Recipe

We’ve all had those evenings—the ones where you want something cozy, cheesy, and quick, but your brain is running on fumes. Enter this Cheesy Cajun Garlic Chicken Rotini. It’s a creamy rotini skillet loaded with flavor, made in just one pan, and guaranteed to bring smiles to your table. The bold Cajun spices wrapped in a velvety cheese sauce hug every spiral of pasta, while the garlicky chicken adds a satisfying punch. And yes, it comes together in just 30 minutes.

If you’ve been craving a Cajun chicken pasta dish that feels like comfort food but still has a little fiery attitude, this is your new weeknight hero. Whether you’re cooking for a family, your partner, or just yourself (because, hey, you deserve it), this chicken skillet dinner is as simple as it is indulgent.

Why You’ll Love This Cheesy Cajun Garlic Chicken Rotini

It’s a full-flavored, one-skillet wonder.
Perfect balance of creamy, cheesy, and spicy.
A cheesy pasta recipe that doesn’t skimp on the garlic or the good stuff.
It’s quick and approachable—even for beginner cooks.
Makes amazing leftovers (if you have any!).

Ingredients

2 boneless, skinless chicken breasts, cut into bite-sized chunks
12 oz rotini pasta
2 tbsp olive oil
2 tbsp Cajun seasoning
1 tsp garlic powder
1/2 tsp onion powder
Salt and pepper, to taste
4 garlic cloves, minced
1 tbsp butter
1 cup heavy cream
1/2 cup chicken broth
1 cup shredded mozzarella cheese
1/2 cup grated Parmesan cheese
1/2 cup shredded cheddar cheese
Fresh parsley, chopped (for garnish)

How to Make This Creamy Rotini Skillet

Bring a large pot of salted water to a boil. Cook rotini until al dente, about 8–10 minutes. Drain and set aside.
While the pasta cooks, heat olive oil in a large skillet over medium-high heat.
Season chicken pieces with Cajun seasoning, garlic powder, onion powder, salt, and pepper.
Add seasoned chicken to the skillet and cook for 6–8 minutes until golden brown and fully cooked. Remove and set aside.
In the same skillet, melt butter and sauté minced garlic for about 1 minute until fragrant.
Pour in heavy cream and chicken broth. Bring to a simmer and cook for 2–3 minutes.
Stir in mozzarella, Parmesan, and cheddar cheeses. Mix until the sauce is smooth and creamy.
Return cooked chicken and rotini to the skillet. Toss to coat everything evenly.
Simmer on low for another 2–3 minutes to let flavors mingle.
Sprinkle with fresh parsley and serve hot!

Tips for a Foolproof Cajun Chicken Pasta

Use a good nonstick or cast iron skillet to prevent the cheese from sticking or burning.
Don’t shy away from seasoning. Cajun spice blends vary, so taste and adjust as needed.
Cheese matters! Freshly shredded cheese melts better and gives a creamier finish.
Want a veggie boost? Stir in baby spinach or sun-dried tomatoes at the end.
Double the batch if you want leftovers. This dish reheats like a dream.

Olivia’s Kitchen Confession

The first time I made this recipe, it was a happy accident. I had chicken to use, a little cream left from another dish, and an almost-forgotten block of cheddar. Cajun seasoning was my wild card, and oh my—did it pay off. Now it’s become one of those “back-pocket” meals I whip up when I want something comforting but don’t want to hover over the stove all night.

It’s also the recipe I use to win over anyone skeptical about spice. The creamy sauce smooths everything out, and once you try a bite, resistance is futile.

What to Serve with Cajun Garlic Chicken Rotini

This dish is rich, so think crisp and fresh for the sides. A simple garden salad with lemon vinaigrette balances the cheesy goodness perfectly. Garlic bread (because more garlic is never a bad idea), steamed green beans, or roasted broccoli are also easy, delicious options.

And if you want to level it up, serve with a sparkling drink or a light white wine. It’s a casual dinner with just a hint of fancy.

How to Store and Reheat

Cool leftovers completely before storing in an airtight container. This creamy rotini skillet keeps well in the fridge for up to 4 days.

To reheat, warm on the stove over low heat or in the microwave. Add a splash of milk or cream if the sauce has thickened. Stir gently until everything is creamy again.

Trust me—it tastes just as delicious the next day, maybe even better!

FAQs

Can I use a different pasta shape?

Absolutely! Penne, fusilli, or even shells work well. Just pick one that holds sauce nicely.

Is this dish very spicy?

It has a mild kick, but it’s customizable. Use less Cajun seasoning or choose a low-sodium, milder blend.

Can I make it ahead?

Yes! Cook and store the components separately, then reheat and combine when ready to serve.

Can I use milk instead of cream?

You can, but the sauce won’t be as rich. For a lighter version, try half-and-half.

Just One More Bite…

Cheesy Cajun Garlic Chicken Rotini is a weeknight wonder that hits every craving: creamy, spicy, cheesy, and just a little bit fancy. Whether it’s your first time making Cajun chicken pasta or you’re a skillet dinner veteran, this recipe will make you feel like a dinner hero.

So go ahead, stir it up, serve it hot, and don’t be surprised when your family starts asking for it every week.

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